The EUMDS registry is celebrating its 10th anniversary:  from the beginning, 10 years ago, the EUMDS registry has collected a great variety of data of over 2500 MDS patients in cooperation with more than 150 sites across Europe. During this symposium both international and national EUMDS investigators will look back to the past 10 years and will share the results obtained so far. We will also look at the future: what are our ambitions for the EUMDS registry for the years ahead?

The international prognostic scoring systems (IPSS and IPSS-Revised) have well established short and medium-term prognosis in MDS, but long-term prognostic indicators (PI) in lower-risk MDS (LR-MDS), largely predominating in elderly patients who often have comorbidities, are less well known. The EUMDS Registry explored longitudinally new PI, other than those integrated in the IPSS-R, such as red blood cell transfusion (RBCT) dependency, RBCT dose density, Health-related Quality of Life (HRQoL), and platelet decline over time and labile plasma iron (LPI). Moreover, most LR-MDS patients die from causes, frequently present in elderly individuals, but indirectly related to MDS.