From a Neuromodulation point of view, Maastricht University Medical Center is a center of excellence in global Neuromodulation. There is long tradition of using Neuromodulation in the treatment of fecal- and urinary incontinence, pain, spasticity, movement disorders, and psychiatric disorders. In the last years, new indications and approaches have been added to this armamentarium, including Neuromodulation for obstipation, irritable bowel syndrome, epilepsy, and tinnitus.