Pathobiology of advanced SM

? Epidemiology

? Diagnosis and classification

? Disease state

? C-findings (SM-related organ damage)

? Other laboratory findings

? Mediator-related symptoms

? Prognosis

? Molecular drivers (KIT D816V/Y)

Quality of life and measures of response in advanced SM

? Quality of life

? Measures of response used in practice and in clinical trials

Overview of treatment options in advanced SM

? Cladribine

? Interferon alpha

? Imatinib

? Masitinib

? Midostaurin

? BLU-285

? Stem cell transplant